Showing posts with label Genetic. Show all posts
Showing posts with label Genetic. Show all posts

Sunday 21 August 2022

Risk Factors For Alcoholism

Alcoholism goes by several names, including alcohol dependence, alcohol abuse, and alcohol use disorder. Recently, it’s been diagnosed as a disease that happens when someone drinks so much that their bodies become addicted to consuming alcohol. It becomes a craving they can’t shake off, no matter how much they drink.


Then, the more they drink, the more they’re affected by it because it causes chemical changes in the brain. These changes make you feel intense pleasure whenever you get a drink.


This acute sense of pleasure makes them drink more often, regardless of the harm it causes. As a result, people who suffer from alcoholism will keep drinking even if it means destroying relationships or losing their jobs. Still, it’s not enough to make them stop drinking.


Even though the exact cause is still unknown, certain risk factors for alcoholism can increase a person’s risk of developing this disorder.


Take a look.


5 Risk Factors for Alcoholism


Alcoholism is a complex disorder with many underlying causes. Therefore, the factors that impact one person can be different for someone else. The factors that can increase the risk for alcoholism are called ‘risk factors.’


Still, you can have one or more of these risk factors and still not develop a drinking problem. Yet, it does make you more susceptible. So, it pays to be extra careful when you’re around alcohol.


Below is a list of the five most common risk factors of this debilitating disease, commonly referred to as alcohol use disorder (AUD).


Mental Health Problems


According to several studies, anyone suffering from a mental health issue is more at risk for developing any type of addiction, including alcoholism. And it’s not just related to alcohol; it can also be an addiction to drugs, opioids, cigarettes, and even food.


A Close Relative with Alcoholism


If one of your parents, siblings, or another close relative has alcoholism, this can increase the risk of developing AUD yourself.


The main reason is the person’s influence on your genetic make-up. Studies show that there are specific genes that react differently to alcohol than others and may even be more vulnerable to its effects.


A second important reason is an alcoholic relative can affect your environment. Whether you realize it or not, growing up around alcoholics can determine whether or not you’ll decide to be swayed to alcohol use later in life.


Binge Drinking


Binge drinking is when a person drinks excessively in a short amount of time.


For men, this is in the range of having more than five drinks in one sitting. As for women, it’s about four or more drinks.


This type of risk factor is more common in young adults between the ages of 18 to 34. Coincidently, this is the time when college students are dealing with the pressures of school. Then, they graduate and have to deal with the responsibilities of balancing work and life.

Nevertheless, many people over the age of 34 are also binge drinkers. It happens more often when they’re in an uncomfortable setting and feel an urge to ease their anxiety so they can relax and have a good time.


Exceed the Average Weekly Limit


According to the Dietary Guidelines for Americans, adult men of the legal drinking age can have two drinks or less per day. For women, it’s one drink or less in a day.


Alternatively, men who drink 14 or more drinks per week, or more than five drinks per day, are at a higher risk of suffering alcohol use disorder.


At the same time, women who drink more than 7 drinks per week are also more liable to suffer from alcoholism.


The number of drinks varies from men and women because of the difference in their body composition. It also takes into account how they metabolize food, with women being more vulnerable to the adverse effects of alcoholic beverages than men.


High-Stress Levels


Stress is a common risk factor for many addictive substances, as well as dozens of mental and physical health disorders, including alcohol use. Research shows that many cases of alcoholism stem from a high-stress situation related to school, work, money, or relationships.


Alcohol acts as a sedative. So, when you’re overly stressed, alcohol becomes the only way to handle your negative emotions, allowing you to de-stress and take your mind off your problems.


Yet, if left unchecked, excessive drinking quickly turns into an addiction. And all those feelings stay bottled up, leading to more serious mental health issues, such as the ones mentioned above.


To Sum Up


If you, or anyone you know, has one or more of these risk factors, it doesn’t necessarily mean it’ll lead to alcoholism. Yet, it does mean you have to be extra careful anytime alcohol is being served. For example, start by making a conscious choice to limit your alcohol intake.


However, if you suspect that you have a drinking problem, then it might be time to seek treatment. There are numerous treatments to choose from, but all are designed with one aim in mind: to help you take your first step towards a better tomorrow.

Monday 6 December 2021

Causes of Hirsutism

Hirsutism is defined as excessive and unwanted facial and/or body (say in the neck, chest and lower abdomen) hair in a male-like formulation. Estimates suggest that it affects between 5% and 15% of women, varying according to characteristics. At least 5% of women of reproductive age suffer from this ailment.


It is a common issue causing significant social and psychological distress mainly among women, but modern diagnosis and treatment can surely take care of the problem.

Causes of Hirsutism 


Before we lunge into the probable causes of hirsutism it is better to remember that it is a sign of hyperandrogenism.


The causes of increased androgen level in hirsutism include:


  • Familial and Idiopathic Hirsutism - These are common causes of hirsutism resulting from peripheral androgen goings-on. It begins in puberty and slowly steps forward. The patients have normal menses, normal testosterone level, 17alpha hydroxyprogesterone and DHEAS. The diagnosis stands on exclusion. 


Idiopathic Cause


Idiopathic cause triggers hirsutism in 6% to 17% of hirsute women. Hirsutism occurs in the body where the circulating levels of androgens and ovulation are normal. The pathophysiological indicators are exaggerated peripheral 5 alpha reductase activity, altered androgen metabolism or different functioning androgen receptors.


Excess secretion by the ovaries (For example tumours, polycystic ovary syndrome (PCOS)).


The most common example is polycystic ovary syndrome, which affects 6% women of the reproductive age bracket. Over 70% patients with PCOS have signs of hyperandrogenism. This is manifested by hyperandrogenaemia and chronic anovulation. 


Polycystic Ovary Syndrome is typified by formation of follicular cysts, which are detected by ultrasound. PCOS is a combination of polycystic ovaries and other typical symptoms like hirsutism, amenorrhea or dysfunctional uterine bleeding, infertility, obesity, irregular menstrual cycles and acne.


This is better diagnosed clinically rather than laboratory findings. The diagnosis of PCOS is based on exclusion, which means this disorder is attributed to patients whose body shows proof of ovulatory dysfunction supported by either clinical or biochemical evidence of hyperandrogenism. 


PCOS is a broad scale disorder with patients ranging from women having regular cycles who have hirsutism to those people who are anovulatory.


Excess secretion by adrenal glands (Examples are congenital adrenal hyperplasia (CAH), Cushing ‘s syndrome, tumours).


Congenital adrenal hyperplasia, or CAH, is a gamut of inherited disorders of adrenal steroidogenesis. In this case diminished cortisol production results in overproduction of androgenic steroids. The common symptoms are acne, menstrual dysfunctions, hirsutism occurring in adolescence or adulthood.


Cushing’s syndrome is caused by amplified production of adrenocorticotropic hormone (ACTH) by the pituitary, adrenal carcinoma/adenoma or secretion of ectopic ACTH. The clinical symptoms of Cushing’s syndrome are quite evident. People with macro-nodular hyperplasia are common prey to intense hirsutism. 

Ovarian or Adrenal Androgen secreting tumours are rare triggers hirsutism/hyperandrogenism. These conditions are indicated by rapid virilization remote from menarche. 


A person may suffer from Hirsutism as a result of using exogenous pharmacologic agents including testosterone, anabolic steroids and danazol (Danocrine).

Oral contraceptives containing nongestural, levonorgestrel and norethindrone are predisposed to more powerful androgenic outcomes than those with norgestinate, desogestrel and ethynodiol diacetate, which have lesser androgenic effects.


Some Rare Causes of Hirsutism 


Medications: Hirsutism may be caused by the medications, which are the sources of hyperprolactinemia.


  • Greater production of growth hormones
  • Hyperinsulinemia
  • Hypothyroidism


The insight into the roots of hirsutism will accelerate the bold step forward, towards the cure of the disease.


Can You Gender Test Your Unborn Child?

With only a few drops of your maternal blood you can find out if baby’s sex is male or female. And you can do it as early as five weeks after conception with the newest technology in the area.


The technology has been tested for the last 14 years - and it works! I am amazed that it is possible. When I was pregnant the last time I got the test - which was very easy to understand and perform. The result came within less than 48 hours, and my husband and I was very happy to learn that I was carrying a baby girl. Our two sons were delighted about their baby sister to come. When the baby girl was born, we had made everything ready for her. No worries about getting pink or blue clothes.


The test is done with cutting-edge, patent-pending technology to attain the earliest gender detection with unprecedented sensitivity and unsurpassed accuracy.


The technique traces the amount of active genetic foetal chromosomal DNA in the maternal blood to determine gender. It is proven, well-documented scientific fact that your baby releases its DNA into your blood plasma. In a lab it is possible to determine foetus-originated-specific chromosome sequence detected in the maternal blood stream.


If there is foetus-originated Y-specific chromosome sequence detected in your blood, you are currently carrying at least one baby boy.


If foetus-originated X-specific chromosome sequence is detected in your blood, you are currently carrying at least one baby girl.


If there is a substantial amount foetus-originated Y-specific chromosome sequence detectable in your sample, indicating that you are carrying at least one baby boy and there is a substantial amount of foetus-originated X-specific chromosome sequence detected in your blood, indicating that you are carrying at least one baby girl. Then you are currently carrying at least one baby girl and boy at this time.

Best Genes

Most females in most species want 3 things.


Women want the best genes.


What are the best genes?


Well. It’s kind of complicated.


We can intuitively define best genes as genes that give us better potential to succeed.


While it’s true, it’s also true that all of us have huge potential to succeed. All of us are under achievers.


But let’s postpone the discussion for latter. Genes do matter. Different genes do give different capability. Some traits, among species, are so important it become common nowadays.


While your success on anything, including getting laid, depends on your choices rather than your genes, your genes still decide how you best achieve success.


Say Mary and Jane lived in the past. Say they were females Cheetah. Mary picks Bob the Slow. Jane picks John the Fastest.


Mary’s son will of course be slow. Slow Cheetah’s died. So Mary’s went extinct. Jane’s son will be fast. Fast Cheetah survives. So Jane’s genes proliferate.


After a while, all females Cheetah’s will be like Jane. Got it?


The same way works if Mary and Jane were human. If Mary pick Bob the poor and Jane pick John the rich. Mary’s son will not be good at making money. Jane’s son will be.


So Mary’s son will have few descendants. Jane’s son will have plenty. After a while, all women will be materialistic like Jane. That while, has come a thousands of years ago.


So, considering that factor alone, a male that want to mate with many females do not need to worry about how to attract females. Women want the best genes and will automagically pick males with the most potential to survive. That’s just one factor though.


Peacock’s elaborate tails do not help his survival. If anything, it reduces it by making the peacocks’ easier target for predators. But peahens like peacocks with long tails. Why?


That’s where the second factor is. That’s the factor of advertising. In advertising, appearance is sometimes more important than real quality. Hence, it is often worthy to sacrifice some real quality for better appearances of it.


After all, some genetic traits like beauty, has no other use besides signalling good genes.

Advertising Your Genes

Customers pick the best product. Women pick the best genes. Well, not quite.


Every soy sauces claim to be number one.


Who knows which one is?


Consumers do not pick which one is best. Consumers pick which one looks best.


Well, you see, like anyone in the world, women do not pick the best genes. Women pick the best looking genes.


How do they know?


All products, including sperms, require advertising. That advertising can actually hurt gene pool, or even life survival. However, if the advertising can improve women’s impressions on the males, some males will do it.


Let’s examine the peacocks elaborate tail. Those tails actually hurt survival.


Those tails attract parasites and predators.


Peacock’s with shorter tails will not attract predators and hence live longer.


However, the fact that most peacocks have long tail is a proof that at least in the past, peacocks with longer tail have survived better in the gene pool.


We know that it happens because peahens are attracted to peacocks with long tail. The reason why the tails are attractive is surprisingly because the tails hurt gene pool survival.


A living peacock with longer tail must have strong capability to fight parasites and run from predators.


Hence, a built in pattern recognition algorithm in all peahen’s mind will correctly conclude that any living peacocks with long tails must have better genes than peacocks with shorter tails.


It’s the same reason why human males spend a lot of money for car, donations, big mansions, and bling bling’s. All those actually hurt gene pool survival. The money used to buy sport cars cannot be used to buy food or health care.


Moreover, a male that show of wealth will often be killed with other males with less to display in their effort to get rid more desirable competitors.


Such killing explains genocide done against capitalists, Jews, and other successfully contributing minorities all over the world.


However, women know that any men that can afford such things must be rich. So women pick such males, and males buy those things.


Advertising of survival capability don’t just end there.

Saturday 4 December 2021

4 Stages of Eclampsia

Someone out there had it out for pregnant girls. As if it isn't hard enough on them already, there is a disorder known as Pre-Eclampsia. Below, we will take a look at what this disorder is characterized by, how it affects you, and how to tell if you have it.


Pre-Eclampsia is a pregnancy disorder involving convulsions. It generally occurs after 20 weeks of pregnancy, and usually with the first child. And as I said before... someone had it out for pregnant girls, because if no signs or symptoms of pre-eclampsia occur, there is still possibilities of eclampsia, which can happen before, during, or after the labour process.


There is only one true way to tell if you are carrying the eclampsia disorder; Eclamptic convulsions. Eclamptic convulsions have a four stages of gruelling pain:


Stage 1 - Unless the woman is aware and watching for this stage, it is generally missed. In stage one the woman will simply roll her eyes, and simultaneously, her hand a face muscles will slightly twitch.


Stage 2 - Shortly after stage one, the teeth will clench, the arms and legs will go rigid, she can bite her tongue, and the face and hand muscles that where twitching will now be clenching. In this stage, the woman will also experience loss of breath for approximately 30 seconds.


Stage 3 - This is where it gets really bad. The muscles will begin to jerk violently, while frothy and slightly bloody saliva will appear. 2 minutes of this until it stops, and then there is a coma, or occasionally heart failure.


Stage 4 -  If not dead, the woman will fall into a deep unconscious state. This can persist for hours, or pass quickly.


Clearly this is not anything to be letting pass by. if any of these symptoms occur, visit your doctor immediately. You could lose 2 lives if you are not properly treated or monitored.