Managing Anaemia Associated With Chemotherapy Treatment

This year, an estimated 1.3 million cancer patients will undergo chemotherapy and more than two-thirds of these patients will develop anaemia, a low red blood cell count. Anaemia is one of the most common side effects of chemotherapy and can negatively affect patients and impact their daily activities. 

 

"Chemotherapy attacks fast-growing cancer cells, but it can also kill normal cells like red blood cells that transport oxygen from the lungs to the body's muscles," said Dr. Ralph Boccia, director of clinical research, Center for Cancer and Blood Disorders, Bethesda, Md. "As a result, the body's tissues are starved of oxygen, making a patient feel short of breath, very weak, faint and tired."

 

More than half of chemotherapy patients report that fatigue, a common symptom of anaemia, affects their daily lives more than any other side effect, including nausea, pain and depression. Further, anaemia is often undertreated, despite the availability of treatments for more than a decade. 

 

Typically, anaemia treatment takes more than two hours per visit. Now, there is a treatment option that provides added convenience from current weekly dosing. Recently, the U.S. Food and Drug Administration approved every-three-week starting dosing of 500 mcg of Aranesp (darbepoetin alfa) for the treatment of chemotherapy-induced anaemia in patients with certain types of cancer. This allows physicians to synchronize anaemia treatment with most chemotherapy schedules, increasing convenience for patients and caregivers by reducing the number of clinic visits and injections for anaemia treatment. 

 

"Receiving anaemia treatment every three weeks on the same schedule as my chemotherapy was convenient for me and my family," said Danielle Mannix, who suffered from anaemia. "We had fewer visits to the doctor for anaemia treatments, which gave me more time for my regular daily activities."

 

Aranesp is contraindicated in patients with uncontrolled hypertension. Erythropoietic therapies may increase the risk of thrombotic events and other serious events.